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Group two received 600 mg of testosterone enanthate each week and followed a progressive weight lifting routinefor five weeks. After that, weight training stopped and the subjects were randomly assigned to group one or to group three for eight weeks. Subjects who had received testosterone therapy were asked to complete an 8-kilo-diameter cross-sectional cross-sectional magnetic resonance imaging (3T MRI) of the brain in an unsupervised manner. Results showed normal results in the volume of gray matter in the regions involved in cognitive, sensory and visual integration. However, in areas where brain connectivity was impaired, such as the medial frontal cortex, there were abnormal signals in regions other than those related specifically to cognition (e.g., the temporal lobe and the cerebellum) and connectivity was impaired over time in the ventral anterior cingulate gyri and posterior cingulate gyrus, both components involved in the regulation of mood.
“The present finding shows that prolonged hormone therapy resulted in structural abnormalities in a region known to be essential for attention and processing time-locked tasks. Thus, testosterone therapy not only interfered with the development of a normal neural network, but also resulted in a decrease in cortical thickness (in the hippocampus and the inferior and medial temporal areas),” read the study.
In response, the researchers have written in Nature Communications that this shows that hormone treatment also disrupts normal brain development, a potential risk factor for a number of neurological diseases: “Exposure of neural circuits, particularly neural networks involved in the representation or processing of temporal and spatial information, to environmental influences may lead to neuronal disorganization and dysfunction.”
“Our study has shown that testosterone treatment resulted in a large brain reduction in the regions that have been associated with attention and executive functions,” says Liao. “These findings suggest that long-term testosterone administration may have adverse effects on normal human brain development and could increase risk of developing neuropsychiatric disorders such as dementia and autism.”
In his research, Liao used a cross-sectional functional magnetic resonance imaging (fMRI) in this study which measured the brain’s functional connectivity using diffusion tensor imaging (DTI). He found that testosterone treatment disrupted brain functional connectivity in the hippocampus and superior temporalgyrus which have been associated with both attention and executive functions.
Source: National Human Genome Research Institute
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